Cosmetic Ingredients
Polygonum Cuspidatum Root Extract
Good Quality Polygonum Cuspidatum Extract Polydatin
Kintainutri have our own production plant, we can provide 98% and 50% content of Polygonum Cuspidatum Extract Polydatin Powder, and the raw material ingredient great potential as a drug candidate or nutraceutical ingredient. Our specifications are 98% and 50%, respectively, and in 2025 we have developed a further 30%. We meticulously source raw materials from premium Polygonum cuspidatum (Japanese knotweed) and utilize advanced extraction, purification, and crystallization technologies to deliver pharmaceutical-grade Polydatin in full compliance with GMP standards.As a leader herbal extract factory certified with cGMP ISO HACCP qualifications Kintainutri, strictly follow the cGMP standard to ensure good quality. If you want to buy pure Polydatin powder, please contact us directly!
What is Polygonum Cuspidatum Extract Polydatin
Polydatin, or Piceid, is a natural precursor and glycoside form of resveratrol with a monocrystalline structure. While it is isolated from the bark of Picea sitchensis or Polygonum cuspidatum. Piceid may be detected in grape; peanut; hop cones; red wines; hop pellets; cocoa-containing products; chocolate products and many daily diets. Piceid possesses anti-inflammatory, immunoregulatory, anti-oxidative and anti-tumor activities. It is shown to mediate a cytotoxic action on colorectal cancer cells by inducing cell arrest and apoptosis. China Manufacturers Suppliers supply high-quality 98% Polydatin powder for sale.
Kintai Polygonum Cuspidatum Extract Polydatin Advantages
High Purity & Potency
Our Polydatin is available in 98%, 50%, and 30% purity grades, rigorously tested by HPLC to ensure consistent bioactive content and optimal efficacy.
Multi-Industry Application
Ideal for Nutraceuticals (antioxidant and cardiovascular support)
Cosmetics (anti-aging and skin-protective agent)
Pharmaceutical research (targeted anti-inflammatory and metabolic studies)
Cosmetics (anti-aging and skin-protective agent)
Pharmaceutical research (targeted anti-inflammatory and metabolic studies)
Strict Quality Control
Produced in a GMP-certified facility with full traceability, supported by COA, MSDS, and comprehensive testing for heavy metals, residual solvents, and microbial contaminants.
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Polygonum Cuspidatum Extract Polydatin COA ＆ Specification
What does Polygonum Cuspidatum Extract Polydatin Benefits
Potent Anti-Cancer Activity
Inhibits proliferation of multiple cancer cell types, including breast, lung, colon, and liver cancer cells.Effective in both hormone-dependent and triple-negative breast cancer by inhibiting the ERα signalling pathway and HER2 phosphorylation. Reduces tumour volume and inhibits lung metastasis in animal models. Blocks the EGFR/Akt/mTOR pathway, enhances cisplatin sensitivity and reverses drug resistance. Effective in non-small cell lung cancer (NSCLC). Regulates Wnt/β-catenin pathway (reduces β-catenin nuclear translocation), inhibits proliferation of colorectal cancer SW480 cells; synergises with 5-FU to enhance therapeutic effect. Inhibits HepG2 cell survival via JAK2/STAT3 pathway and inhibits VEGF-mediated angiogenesis.
Powerful Antioxidant & Anti-Inflammatory Effects
Polydatin's antioxidant capacity far exceeds that of its glycoside resveratrol (due to the glycoside structure to enhance stability, through direct scavenging of free radicals, up-regulation of endogenous antioxidant defences, inhibition of oxidative stress-related pathways to antioxidant; through the regulation of classical inflammatory signaling pathways and immune cell function to achieve inhibition of the NF-κB pathway (the core mechanism), the regulation of the NLRP3 inflammatory vesicles, balancing the immune cells polarization, and protection of vascular endothelium) inflammation; and achieve synergistic effects through the interplay of antioxidant and anti-inflammatory: ROS activate NF-κB, while inflammatory factors promote ROS production. Polydatin breaks this cycle by inhibiting both simultaneously (e.g., attenuating hepatic fibrosis in NAFLD).
Growing Demand in Multiple Industries
Can be used in dietary supplements, functional foods, cosmetics, pharmaceutical research.
What does Polygonum Cuspidatum Extract Polydatin Application
1.Pharmaceuticals:It can be used as an adjunct ingredient in drug development for cardiovascular diseases, hepatitis and neurodegenerative diseases. Clinical trials are underway to explore the use of thujaplicin in antifibrotic and anti-ischemia reperfusion injury applications.According to the previous studies, polydatin is a versatile natural compound and exerts significantly protective and curative effects on oxidative stress-associated liver diseases via various molecular mechanisms, including amelioration of liver function and insulin resistance, inhibition of proinflammatory cytokines, lipid accumulation and endoplasmic reticulum stress and autophagy.
2.Nutritional healthcare supplement: Made into dietary supplements for anti-aging, liver protection, and immunity enhancement.
Polydatin is the most abundant form of resveratrol in nature. Polydatin shows many pharmacological effects confirmed by numerous investigations, including cardiovascular protection, neuroprotection, anti-inflammation, immunoregulation, anti-oxidation, anti-tumour and liver and lung protective effects. Polydatin has found its way into clinical trials for the treatment of hemorrhagic shock and irritable bowel syndrome.
Polydatin is the most abundant form of resveratrol in nature. Polydatin shows many pharmacological effects confirmed by numerous investigations, including cardiovascular protection, neuroprotection, anti-inflammation, immunoregulation, anti-oxidation, anti-tumour and liver and lung protective effects. Polydatin has found its way into clinical trials for the treatment of hemorrhagic shock and irritable bowel syndrome.
3.Cosmetics: Added to anti-aging, whitening and sunscreen products to utilize its antioxidant and anti-inflammatory properties.
4.Food Field:Used as a natural antioxidant to extend the shelf life of food or in functional beverages.
Polygonum Cuspidatum Extract Polydatin dosage
1. Can be used as a dietary supplement or for healthcare purposes
Daily antioxidant support: 50~200 mg/day
Anti-inflammatory/cardiovascular support: 100~300 mg/day (divided into 2 doses)
2. For scientific research or clinical trials
In vitro study: commonly used concentration 10~100 μM (need to be optimized according to cell type)
Animal experiment: mouse model usually 10~50 mg/kg/day
3. For cosmetic additives
Skin care formulations: 0.1%~1% concentration (need to test stability)
Cautions
Impact of purity: 98% high purity products need to be calculated accurately, low purity (such as 30%) need to adjust the dosage.
Safety: Current studies show low toxicity, but long-term high doses (>500 mg/day) require clinical monitoring.
Regulatory differences: when used as a new resource food or drug, it needs to comply with local regulations.
Safety of Polygonum Cuspidatum Extract Polydatin
Drug Interactions: May inhibit CYP3A4 enzymes; caution is required when used in combination with anticoagulants (e.g. warfarin) and immunosuppressants.
Allergy Risk: Very few people are allergic to polyphenols, small dose testing is recommended for initial use.
Allergy Risk: Very few people are allergic to polyphenols, small dose testing is recommended for initial use.
Quality Control: Choose GMP certified products to avoid heavy metal and solvent residues (COA report required for support)
Why Choose Polydatin Powder by Kintainutri®?
1. We promise that our raw materials are naturally grown without any additives.We have strict quality control and certification, High Purity Polydatin ≥ 98% HPLC purity, Kosher, Halal and SGS compliant. And we have strict batch testing for heavy metals, solvents and microbial contaminants.
2. We provide customized extraction solutions to produce Polydatin powder in various specifications tailored to your requirements.We have reliable global supply chain, stable production capacity and competitive price. Bulk demand can be met.
3. Our production facilities hold internationally recognized certifications including GMP, ISO 9001, ISO 22000, HACCP, KOSHER, and HALAL, guaranteeing the highest standards for your peace of mind.
Shipping & Packaging
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● Packaging: Inside food grade bag, outer aluminum foil bag.25kg use double-layer plastic container/fiber drum.Or your choice.● OEM Service Available: Customized packaging available, click here to know more.● Shipping: DHL / FEDEX / EMS/ BY AIR / BY SEA● American Warehouse: KINTAI put over 100 natural plant extract ingredients in our US warehouse for fast delivery.● Payment: We accept payment by T/T, L/C, Paypal, and Wester Union.Please contact us and we will guide you with an easy and professional way for your order.
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